TLR9 antibody (Internal Region)

Catalog No. ABIN920629

This Rabbit Polyclonal antibody specifically detects TLR9 in WB and ICC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TLR9 antibody (Internal Region) (ABIN920629)

Target: TLR9 (Toll-Like Receptor 9 (TLR9))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLR9 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Product Details anti-TLR9 Antibody

Binding Specificity: Internal Region

Characteristics: Positive Control: Jurkat cell lysate. Located in the membrane, and highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.

Purification: Antigen Immunoaffinity purified

Immunogen: Rabbit polyclonal TLR9 antibody was raised against a peptide corresponding to 15 amino acids near the center of human TLR9.

Isotype: IgG

Application Details

Application Notes: Western blot: use at 0.5-1 µg/mL

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.02% sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for TLR9

Target: TLR9 (Toll-Like Receptor 9 (TLR9))

Background: Toll-like receptors (TRLs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. TLR9 forms a subfamily with TLR7 and TLR8 that recognize viral RNA and CpG DNA sequences and are localized in intracellular acidic compartments such as the phagolysosome. Unlike other TLRs which act through adaptor molecules such as TOLLIP, TIRAP, TRIF, and MyD88 to activate various kinases and transcription factors to respond to potential infection, TRL9 is strictly dependent on MyD88. Synonyms:

Molecular Weight: 116 kDa

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades