TLR3 antibody (N-Term)

Catalog No. ABIN920638

This Rabbit Polyclonal antibody specifically detects TLR3 in WB and IHC. It exhibits reactivity toward Human and Mouse.

Quick Overview for TLR3 antibody (N-Term) (ABIN920638)

Target: TLR3 (Toll-Like Receptor 3 (TLR3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLR3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TLR3 Antibody

Binding Specificity: N-Term

Characteristics: Positive Control: Located in the membrane and expressed at high levels in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors.

Purification: Antigen Immunoaffinity purified

Immunogen: Rabbit polyclonal TLR3 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of TLR3.

Isotype: IgG

Application Details

Application Notes: Western blot: use at 1-2 µg/mL

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.02% sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for TLR3

Target: TLR3 (Toll-Like Receptor 3 (TLR3))

Background: Toll-like receptors (TRLs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR3 is known to recognize viral double-stranded RNA, as a molecular pattern associated with viral infection. Recently it has been shown to recognize viruses such as influenza A and West Nile Virus and can mediate entry of at least West Nile virus. Synonyms:

Molecular Weight: 103.8 kDa

Pathways: TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades