TLR6 antibody (N-Term)

Catalog No. ABIN920640

The Rabbit Polyclonal anti-TLR6 antibody (ABIN920640) specifically detects TLR6 in WB and ICC. The antibody is reactive with Human and Mouse samples.

Quick Overview for TLR6 antibody (N-Term) (ABIN920640)

Target: TLR6 (Toll-Like Receptor 6 (TLR6))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLR6 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Product Details anti-TLR6 Antibody

Binding Specificity: N-Term

Characteristics: Positive Control: Jurkat cell lysate. Located in the membrane TLR6 is detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre- dendritic cells and dermal microvessel endothelial cells.

Purification: Antigen Immunoaffinity purified

Immunogen: Rabbit polyclonal TLR6 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of TLR6.

Isotype: IgG

Application Details

Application Notes: Western blot: use at 1-2 µg/mL. Immunocytochemistry: use at 10 µg/mL

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.02% sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for TLR6

Target: TLR6 (Toll-Like Receptor 6 (TLR6))

Background: Toll-like receptors (TRLs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR6 was first identified as a close homolog of TLR1, sharing 69% sequence identity. Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 heterodimers coordinate macrophage activation by Gram-positive bacteria and the yeast cell wall particle zymosan. Activation of these complexes not only initiates pro-inflammatory cascades, but can also lead to apoptotic responses. Synonyms:

Molecular Weight: 96 kDa

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades