TWEAK antibody (N-Term)

Catalog No. ABIN926993

The Rabbit Polyclonal anti-TWEAK antibody is suitable to detect TWEAK in samples from Human, Mouse and Dog. It has been validated for WB.

Quick Overview for TWEAK antibody (N-Term) (ABIN926993)

Target: TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))

Reactivity: Human, Mouse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TWEAK antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TWEAK Antibody

Binding Specificity: N-Term

Cross-Reactivity: Mouse (Murine), Dog (Canine)

Purification: Purified

Immunogen: TNFSF12 antibody was raised in rabbit using the N terminal of TNFSF12 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

TNFSF12 Blocking Peptide, , is also available for use as a blocking control in assays to test for specificity of this TNFSF12 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for TWEAK

Target: TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))

Alternative Name: TNFSF12

Background: TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Synonyms: Polyclonal TNFSF12 antibody, Anti-TNFSF12 antibody, tumor necrosis factor, ligand superfamily, member 12 antibody.

Pathways: Apoptosis