GTF2H2 antibody

Catalog No. ABIN930961

This Mouse Monoclonal antibody specifically detects GTF2H2 in DB. It exhibits reactivity toward Human.

Quick Overview for GTF2H2 antibody (ABIN930961)

Target: GTF2H2 (General Transcription Factor IIH, Polypeptide 2, 44kDa (GTF2H2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GTF2H2 antibody is un-conjugated

Application: Dot Blot (DB)

Clone: GTF2F6A10

Product Details anti-GTF2H2 Antibody

Cross-Reactivity: Human

Cross-Reactivity (Details): Other species not studied.

Purification: Protein G affinity chromatography

Immunogen: GTF2 H2 antibody was raised in mouse using recombinant Human General Transcription Factor Iih, Polypeptide 2, 42 da

Isotype: IgG1

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: GTF2 H2 antibody in PBS (3.0 mM KCl,1.5 mM KH2 O4, 140 mM NaCl, 8.0 mM Na2 P04 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3).

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.

Target Details for GTF2H2

Target: GTF2H2 (General Transcription Factor IIH, Polypeptide 2, 44kDa (GTF2H2))

Alternative Name: GTF2H2

Background: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Synonyms: Monoclonal GTF2H2 antibody, Anti-GTF2H2 antibody, General transcription factor IIH subunit 2 antibody, BTF2 antibody, TFIIH antibody, BTF2P44 antibody, T-BTF2P44 antibody.

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling