Chitotriosidase 1 antibody (AA 22-137)

Catalog No. ABIN931480

Product Details anti-Chitotriosidase 1 Antibody

Target: Chitotriosidase 1 (CHIT1) (Chitotriosidase (CHIT1))

Binding Specificity: AA 22-137

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Chitotriosidase 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Immunogen: CHIT1 antibody was raised in Mouse using a purified recombinant fragment of CHIT1(aa22-137) expressed in E. coli as the immunogen.

Clone: 1D9G2-1D9G4-2B4G3

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10,000, WB: 1:500-1:2000
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Supplied as a liquid in ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term storage. Store at -20 °C for long term storage.

Target Details for Chitotriosidase 1

Target: Chitotriosidase 1 (CHIT1) (Chitotriosidase (CHIT1))

Alternative Name: CHIT1 (CHIT1 Products)

Synonyms: CHI3 antibody, CHIT antibody, CHITD antibody, CHIT1 antibody, chio antibody, 2300002L19Rik antibody, chitinase 1 antibody, chitinase 1 (chitotriosidase) antibody, CHIT1 antibody, chit1 antibody, Chit1 antibody

Background: CHIT1 is a 50 kDa secreted glycoprotein that belongs to glycohydrolase family # 18. It is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Synonyms: Monoclonal CHIT1 antibody, Anti-CHIT1 antibody, Chitinase 1 antibody, Chitotriosidase antibody, CHIT antibody.