ERCC6 antibody

Catalog No. ABIN932472

The Mouse Monoclonal anti-ERCC6 antibody (Clone 553C5a) (ABIN932472) specifically detects ERCC6 in DB. The antibody is reactive with Human samples.

Quick Overview for ERCC6 antibody (ABIN932472)

Target: ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ERCC6 antibody is un-conjugated

Application: Dot Blot (DB)

Clone: 553C5a

Product Details anti-ERCC6 Antibody

Cross-Reactivity: Human

Cross-Reactivity (Details): Other species not studied.

Purification: Protein G affinity chromatography

Immunogen: ERCC6 antibody was raised in mouse using recombinant Human Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (Ercc6)

Isotype: IgG2b

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: ERCC6 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.

Target Details for ERCC6

Target: ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))

Alternative Name: ERCC6

Background: This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The protein has ATP-stimulated ATPase activity, there are contradictory publications reporting presence or absence of helicase activity. The protein appears to interact with several transcription and excision repair proteins, and may promote complex formation at repair sites. Mutations in this gene result in Cockayne syndrome type B. Synonyms: Monoclonal ERCC6 antibody, Anti-ERCC6 antibody, Excision repair cross complementing rodent repair deficiency, complementation group 6 antibody, CSB antibody, CKN2 antibody, COFS antibody, ARMD5 antibody, COFS1 antibody, RAD26 antibody.

Pathways: DNA Damage Repair, Chromatin Binding