Integrin Alpha2b antibody (CD41)

Catalog No. ABIN94106

Product Details anti-Integrin Alpha2b Antibody

Target:

Integrin Alpha2b (CD41)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Integrin Alpha2b antibody is un-conjugated

Application: Flow Cytometry (FACS)

Specificity: The antibody MEM-06 reacts with CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain, 120 kDa) and GPIIb beta (light chain, 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
Workshop: HLDA 10

Cross-Reactivity (Details): Human

Purification: Purified by protein-A affinity chromatography

Purity: > 95 % (by SDS-PAGE)

Immunogen: Leukocytes of patient suffering from LGL-type leukaemia.

Clone: MEM-06

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.

Target Details for Integrin Alpha2b

Target:

Integrin Alpha2b (CD41)

Alternative Name: CD41 (CD41 Antibody Abstract)

Synonyms: AI172977, CD41, CD41B, GpIIb, alphaIIb, BDPLT16, BDPLT2, GP2B, GPIIb, GT, GTA, HPA3, integrin alpha 2b, integrin subunit alpha 2b, Itga2b, ITGA2B

Background: CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.

Pathways: Integrin Complex