Integrin Alpha2b antibody (CD41)

Details for Product anti-CD41 Antibody No. ABIN94106
Antigen
Reactivity
Human
369
95
28
16
11
9
5
4
2
2
2
2
1
1
1
1
Host
Mouse
298
76
60
Clonality (Clone)
Monoclonal ()
Conjugate
This Integrin Alpha2b antibody is un-conjugated
59
42
41
15
10
6
5
5
4
3
3
3
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
306
93
75
71
56
49
33
20
20
13
7
6
6
3
3
1
1
1
Options
Immunogen Leukocytes of patient suffering from LGL-type leukaemia.
Clone MEM-06
Isotype IgG1
Specificity The antibody MEM-06 reacts with CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain, 120 kDa) and GPIIb beta (light chain, 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
Workshop: HLDA 10
Cross-Reactivity (Details) Human
Purification Purified by protein-A affinity chromatography
Purity > 95 % (by SDS-PAGE)
Antigen
Alternative Name CD41 (CD41 Antibody Abstract)
Background CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.
Pathways Integrin Complex
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Supplier Images
Image no. 1 for anti-Integrin Alpha2b (CD41) antibody (ABIN94106) Surface staining of human platelets with anti-human CD41 (MEM-06) PE.