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CD59 antibody

CD59 Reactivity: Human, Pig FACS, Func Host: Mouse Monoclonal MEM-129 unconjugated
Catalog No. ABIN94204
  • Target See all CD59 Antibodies
    CD59
    Reactivity
    • 137
    • 14
    • 9
    • 8
    • 5
    • 2
    • 2
    • 1
    • 1
    Human, Pig
    Host
    • 89
    • 69
    • 6
    • 4
    Mouse
    Clonality
    • 96
    • 69
    • 1
    Monoclonal
    Conjugate
    • 77
    • 21
    • 16
    • 13
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD59 antibody is un-conjugated
    Application
    • 100
    • 70
    • 46
    • 40
    • 31
    • 28
    • 25
    • 15
    • 15
    • 14
    • 13
    • 11
    • 11
    • 11
    • 8
    • 3
    • 3
    • 3
    • 1
    • 1
    Flow Cytometry (FACS), Functional Studies (Func)
    Specificity
    The antibody MEM-129 reacts with CD59 (Protectin), a 18-20 kDa glycosylphosphatidylinositol (GPI)-anchored extracellular glycoprotein expressed on all hematopoietic cells, it is widely present on cells in all tissus.
    Cross-Reactivity (Details)
    Human, Porcine
    Purification
    Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).
    Purity
    > 95 % (by SDS-PAGE)
    Immunogen
    Human peripheral blood lymphocytes
    Clone
    MEM-129
    Isotype
    IgM
    Top Product
    Discover our top product CD59 Primary Antibody
  • Application Notes
    Functional application: The antibody MEM-129 activates T cells.
    Flow cytometry: Recommended dilution: 1-4 μg/mL.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    HEPES buffered saline (HBS), pH 7.0
    Preservative
    Azide free
    Handling Advice
    Do not freeze.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Do not freeze.
  • Stulnig, Berger, Sigmund, Stockinger, Horejsí, Waldhäusl: "Signal transduction via glycosyl phosphatidylinositol-anchored proteins in T cells is inhibited by lowering cellular cholesterol." in: The Journal of biological chemistry, Vol. 272, Issue 31, pp. 19242-7, (1997) (PubMed).

    Olweus, Lund-Johansen, Terstappen: "CD64/Fc gamma RI is a granulo-monocytic lineage marker on CD34+ hematopoietic progenitor cells." in: Blood, Vol. 85, Issue 9, pp. 2402-13, (1995) (PubMed).

  • Target
    CD59
    Alternative Name
    CD59 (CD59 Products)
    Synonyms
    16.3A5 antibody, 1F5 antibody, EJ16 antibody, EJ30 antibody, EL32 antibody, G344 antibody, HRF-20 antibody, HRF20 antibody, MAC-IP antibody, MACIF antibody, MEM43 antibody, MIC11 antibody, MIN1 antibody, MIN2 antibody, MIN3 antibody, MIRL antibody, MSK21 antibody, p18-20 antibody, Cd59a antibody, Cd59b antibody, MACIP antibody, CD59 molecule (CD59 blood group) antibody, CD59 molecule antibody, CD59 antibody, Cd59 antibody
    Background
    CD59 Molecule,CD59 (protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.,MACIF, MAC-IP, protectin, MIRL, HRF-20, HRF20, 1F5, MIN
    Gene ID
    966
    UniProt
    P13987
    Pathways
    Complement System
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