SOCS3 antibody

Catalog No. ABIN94467

This anti-SOCS3 antibody is a Mouse Monoclonal antibody detecting SOCS3 in WB. Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for SOCS3 antibody (ABIN94467)

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SOCS3 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: SO1

Product Details anti-SOCS3 Antibody

Purpose: Anti-SOCS3 Purified

Specificity: The antibody SO1 reacts with SOCS3, an intracellular cytokine signaling inhibitor.

Cross-Reactivity (Details): Human

Purification: Purified by protein-A affinity chromatography.

Purity: > 95 % (by SDS-PAGE)

Immunogen: Full-length SOCS3 protein.

Isotype: IgG2b

Application Details

Application Notes: Western blotting: Positive control: HeLa human cervix carcinoma cell line, reducing conditions.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

References for anti-SOCS3 antibody (ABIN94467)

Neuwirt, Puhr, Cavarretta, Mitterberger, Hobisch, Culig: "Suppressor of cytokine signalling-3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion." in: Endocrine-related cancer, Vol. 14, Issue 4, pp. 1007-19, (2007) (PubMed).

Target Details for SOCS3

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Alternative Name: SOCS3

Background: Suppressor of cytokine signaling 3,SOCS3 (suppressor of cytokine signaling 3), also known as CIS3 (cytokine-inducible SH2 protein 3) is a negative regulator of particular cytokine signaling pathways. SOCS3 is induced by a variety of cytokines and other stimuli, such as erythropoietin, leptin and lipopolysaccharides and inhibits tyrosinkinase activity of JAK kinases, or e.g. JNK phosphorylation. SOCS3 modulates cytokine-mediated and neoplastic-proliferative responses and is involved also in maintaining leukocytes in quiescent state until antigen stimulation.,SOCS-3, CIS3, SSI3

Gene ID: 9021

UniProt: Q6FI39

Pathways: JAK-STAT Signaling, Response to Growth Hormone Stimulus, Hepatitis C