ADAM9 antibody (Extracellular Domain)

Catalog No. ABIN950269

This Rat Monoclonal antibody specifically detects ADAM9 in WB. It exhibits reactivity toward Mouse.

Quick Overview for ADAM9 antibody (Extracellular Domain) (ABIN950269)

Target: ADAM9 (ADAM Metallopeptidase Domain 9 (ADAM9))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This ADAM9 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 7D10

Product Details anti-ADAM9 Antibody

Binding Specificity: Extracellular Domain

Purification: Protein A/G Affinity Chromatography

Immunogen: Purified Recombinant ADAM9 extracellular domain.

Isotype: IgG2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.

Buffer: 0.2 μm filtered PBS solution, None

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 months.

Expiry Date: 6 months

Target Details for ADAM9

Target: ADAM9 (ADAM Metallopeptidase Domain 9 (ADAM9))

Alternative Name: ADAM9 / MDC9

Background: ADAM9, also known as MDC9 or meltrin γ, is a member of the ADAM family that contains a disintegrin and metalloprotease-like domain. Like other membrane-anchored ADAMs, ADAM9 consists of a pro domain with a cysteine switch and furin cleavage sequence, a catalytic domain with the zinc-binding site and Metturn expected for reprolysins, a disintegrin like domain, a cysteine-rich domain, an EGF-like domain, a transmembrane domain, and the cytoplasmic domain. ADAM9 is able to cleave peptides corresponding to cleavage sites of tumor necrosis factorα (TNFα), the p75 TNF receptor, the β-amyloid protein precursor, and the c-kit ligand1, implying that it may participate in shedding of these membrane proteins. In fact, ADAM9 has been shown to shed membrane-anchored heparin-binding EGF-like growth factor. In addition, it also cleaves oxidized insulin B-chain and fibronectin. Besides its catalytic activity, ADAM9 functions as an adhesion molelcule through binding of its disintegrin domain to integrins such as αvβ5 and α6β1. The cytoplasmic domain of ADAM9 interacts with Src homology 3 (SH3)containing proteins and protein kinase C, and may mediate different signaling pathways. ADAM9 is widely expressed in tissues.Synonyms: Cellular disintegrin-related protein, Disintegrin and metalloproteinase domain-containing protein 9, KIAA0021, MCMP, MLTNG, Meltrin gamma, Metalloprotease/disintegrin/cysteine-rich protein 9, Myeloma cell metalloproteinase

Gene ID: 10090

UniProt: Q61072

Pathways: Cellular Response to Molecule of Bacterial Origin, SARS-CoV-2 Protein Interactome