AP2M1 antibody (C-Term)

Catalog No. ABIN950447

The Rabbit Polyclonal anti-AP2M1 antibody is suitable to detect AP2M1 in samples from Human and Mouse. It has been validated for WB and EIA.

Quick Overview for AP2M1 antibody (C-Term) (ABIN950447)

Target: AP2M1 (Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AP2M1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-AP2M1 Antibody

Binding Specificity: AA 386-415, C-Term

Specificity: This antibody recognizes AP2 complex subunit mu-1.

Cross-Reactivity (Details): Species reactivity (expected):Bovine, Chicken, Monkey, Rat, Xenopus, Zebrafish, C. elegansSpecies reactivity (tested):Human and Mouse.

Purification: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 386-415 amino acids from the C-terminal region of Human AP2M1 Genename: AP2M1

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for AP2M1

Target: AP2M1 (Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1))

Background: This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene.Synonyms: AP-2 mu-2 chain, Adaptin-mu2, CLAPM1, Clathrin assembly protein complex 2 medium chain, Clathrin coat assembly protein AP50, Clathrin coat-associated protein AP5, HA2 50 kDa subunit, KIAA0109, Plasma membrane adaptor AP-2 50 kDa protein

Molecular Weight: 49655 Da

Gene ID: 1173

NCBI Accession: NP_001020376

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation, SARS-CoV-2 Protein Interactome