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ASXL1 antibody (AA 521-549)

ASXL1 Reactivity: Human, Mouse WB, FACS, IF, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN950543
  • Target See all ASXL1 Antibodies
    ASXL1 (Additional Sex Combs Like 1 (ASXL1))
    Binding Specificity
    • 8
    • 6
    • 6
    • 6
    • 3
    • 2
    • 1
    AA 521-549
    Reactivity
    • 27
    • 24
    • 1
    Human, Mouse
    Host
    • 29
    • 2
    Rabbit
    Clonality
    • 29
    • 2
    Polyclonal
    Conjugate
    • 14
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ASXL1 antibody is un-conjugated
    Application
    • 22
    • 16
    • 14
    • 13
    • 13
    • 5
    • 3
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects ASXL1 at Center.
    Cross-Reactivity (Details)
    Species reactivity (tested):Mouse.
    Purification
    Affinity Chromatography on Protein A
    Immunogen
    KLH conjugated synthetic peptide between 521-549 amino acids from the Central region of human ASXL.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product ASXL1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS, 0.09 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    ASXL1 (Additional Sex Combs Like 1 (ASXL1))
    Alternative Name
    ASXL1 (ASXL1 Products)
    Synonyms
    asxl1 antibody, MGC83850 antibody, mKIAA0978 antibody, BOPS antibody, MDS antibody, additional sex combs like 1, transcriptional regulator L homeolog antibody, additional sex combs like 1, transcriptional regulator antibody, additional sex combs like 1 antibody, asxl1.L antibody, ASXL1 antibody, asxl1 antibody, Asxl1 antibody
    Background
    This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.Synonyms: Additional sex combs-like protein 1, KIAA0978, Putative Polycomb group protein ASXL1
    Molecular Weight
    165432 Da
    Gene ID
    171023
    NCBI Accession
    NP_056153
    Pathways
    Retinoic Acid Receptor Signaling Pathway
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