Coagulation Factor IX antibody
Quick Overview for Coagulation Factor IX antibody (ABIN951594)
Target
See all Coagulation Factor IX (F9) AntibodiesReactivity
Host
Clonality
Conjugate
Application
Clone
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Specificity
- Recognises Factor IX
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Purification
- Protein G Chromatography
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Immunogen
- Full length native protein (purified) (Human).
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Isotype
- IgG1
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Concentration
- 3.5 mg/mL
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Buffer
- 0.05 M Sodium Phosphate, 0.5 M NaCl, 1 mM EDTA, pH 6.6
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Handling Advice
- Avoid repeated freezing and thawing.
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Storage
- -80 °C
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Storage Comment
- Store at -70 °C.
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- Coagulation Factor IX (F9)
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Background
- Coagulation Factor IX (F9) circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease.Synonyms: Christmas factor, PTC, Plasma thromboplastin component
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Gene ID
- 2158
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NCBI Accession
- NP_000124
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UniProt
- P00740
Target
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