DVL1 antibody (Middle Region)

Catalog No. ABIN951918

The Rabbit Polyclonal anti-DVL1 antibody (ABIN951918) specifically detects DVL1 in WB, IF, IHC (p) and EIA. The antibody is reactive with Human samples.

Quick Overview for DVL1 antibody (Middle Region) (ABIN951918)

Target: DVL1 (Dishevelled Segment Polarity Protein 1 (DVL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DVL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-DVL1 Antibody

Binding Specificity: AA 441-470, Middle Region

Specificity: This antibody recognizes Human Dishevelled-1 / DVL1 (Center).

Purification: Affinity Chromatography on Proteinn A

Immunogen: KLH conjugated synthetic peptide between 441-470 amino acids from the Central region of Human DVL1

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for DVL1

Target: DVL1 (Dishevelled Segment Polarity Protein 1 (DVL1))

Alternative Name: Dishevelled-1 / DVL1

Background: DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.Synonyms: DSH homolog 1, DVL-1, Segment polarity protein dishevelled homolog DVL-1

Molecular Weight: 75187 Da

Gene ID: 1855

NCBI Accession: NP_004412

Pathways: WNT Signaling, Synaptic Membrane, Skeletal Muscle Fiber Development