LIG3 antibody (C-Term)

Catalog No. ABIN951931

This Rabbit Polyclonal antibody specifically detects LIG3 in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for LIG3 antibody (C-Term) (ABIN951931)

Target: LIG3 (Ligase III, DNA, ATP-Dependent (LIG3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LIG3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-LIG3 Antibody

Binding Specificity: AA 792-822, C-Term

Specificity: This antibody recognizes Human DNA ligase 3 (C-term).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 792-822 amino acids from the C-terminal region of Human DNA ligase 3 Genename: LIG3

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for LIG3

Target: LIG3 (Ligase III, DNA, ATP-Dependent (LIG3))

Alternative Name: DNA Ligase 3

Background: This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized.Synonyms: DNA ligase 3, DNA ligase III, EC=6.5.1.1, LIG-3, LIG3, Polydeoxyribonucleotide synthase [ATP] 3

Molecular Weight: 112907 Da

Gene ID: 3980

NCBI Accession: NP_002302

Pathways: DNA Damage Repair