FZD6 antibody (Middle Region)

Catalog No. ABIN952410

The Rabbit Polyclonal anti-FZD6 antibody (ABIN952410) specifically detects FZD6 in WB and EIA. The antibody is reactive with Human samples.

Quick Overview for FZD6 antibody (Middle Region) (ABIN952410)

Target: FZD6 (Frizzled Family Receptor 6 (FZD6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FZD6 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-FZD6 Antibody

Binding Specificity: AA 493-520, Middle Region

Specificity: This antibody recognizes Human FZD6 (Center).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 493-520 amino acids from the Central region of human FZD6

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for FZD6

Target: FZD6 (Frizzled Family Receptor 6 (FZD6))

Alternative Name: FZD6

Background: This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants.Synonyms: Frizzled-6, Fz-6, hFz6

Molecular Weight: 79292 Da

Gene ID: 8323

NCBI Accession: NP_001158087

Pathways: WNT Signaling, Tube Formation