Glypican 3 antibody (C-Term)

Catalog No. ABIN952555

This Rabbit Polyclonal antibody specifically detects Glypican 3 in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for Glypican 3 antibody (C-Term) (ABIN952555)

Target: Glypican 3 (GPC3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glypican 3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-Glypican 3 Antibody

Binding Specificity: AA 464-494, C-Term

Specificity: This antibody reacts to GPC3.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 464-494 amino acids from the C-terminal region of human GPC3

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Glypican 3

Target: Glypican 3 (GPC3)

Alternative Name: Glypican-3 / GPC3

Background: Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.Synonyms: GTR2-2, Intestinal protein OCI-5, MXR7, OCI5

Molecular Weight: 65563 Da

Gene ID: 2719

NCBI Accession: NP_004475

Pathways: Glycosaminoglycan Metabolic Process