ID4 antibody (Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein) (AA 1-30)

Details for Product anti-ID4 Antibody No. ABIN952816, Supplier: Log in to see
Antigen
  • Idb4
  • bHLHb27
  • cb547
  • fb77d04
  • sb:cb547
  • wu:fb77d04
  • zgc:123214
  • bhlhb27
  • id4
  • id4a
  • idb4
  • IDB4
  • inhibitor of DNA binding 4
  • inhibitor of DNA binding 4, HLH protein
  • inhibitor of DNA binding 4, HLH protein S homeolog
  • Id4
  • id4
  • id4.S
  • ID4
Epitope
AA 1-30, N-Term
17
16
9
3
2
2
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
90
58
42
6
5
3
2
1
1
1
1
1
Host
Rabbit
70
20
Clonality
Polyclonal
Conjugate
This ID4 antibody is un-conjugated
4
4
4
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
61
43
29
16
13
10
7
1
1
1
Options
Supplier
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Immunogen KLH conjugated synthetic peptide between 1~30 amino acids from the N-terminal region of Human ID4 / BHLHB27
Isotype Ig Fraction
Specificity This antibody recognizes Human and Mouse ID4 / BHLHB27 (N-term).
Purification Protein A column, followed by peptide affinity purification
Plasmids, Primers & others Plasmids, Primers & others ID4 products on genomics-online (e.g. as negative or positive controls)
Alternative Name ID4 / BHLHB27 (ID4 Antibody Abstract)
Background ID4 is transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins.Synonyms: Class B basic helix-loop-helix protein 27, DNA-binding protein inhibitor ID-4, Inhibitor of DNA binding 4
Molecular Weight 16622 Da
Gene ID 3400
NCBI Accession NP_001537
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4) (AA 1-30), (N-Term) antibody (ABIN952816) Flow cytometric analysis of 293 cells using ID4 Antibody (N-term) Cat.-No AP52145PU-N...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4) (AA 1-30), (N-Term) antibody (ABIN952816) Immunohistochemistry analysis in formalin fixed and paraffin embedded bladder carcino...
Western Blotting (WB) image for anti-Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4) (AA 1-30), (N-Term) antibody (ABIN952816) Western blot analysis of ID4 Antibody (N-term) Cat.-No AP52145PU-N in Mouse bladder t...
Background publications Fontemaggi, DellOrso, Trisciuoglio, Shay, Melucci, Fazi, Terrenato, Mottolese, Muti, Domany, Del Bufalo, Strano, Blandino: "The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis." in: Nature structural & molecular biology, Vol. 16, Issue 10, pp. 1086-93, 2009 (PubMed).

Uhm, Lee, Lee, Park, Kim, Kim, Kim, Park: "Differential methylation pattern of ID4, SFRP1, and SHP1 between acute myeloid leukemia and chronic myeloid leukemia." in: Journal of Korean medical science, Vol. 24, Issue 3, pp. 493-7, 2009 (PubMed).

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