KREMEN2 antibody (Middle Region)

Catalog No. ABIN953114

The Rabbit Polyclonal anti-KREMEN2 antibody is suitable to detect KREMEN2 in samples from Human. It has been validated for WB and EIA.

Quick Overview for KREMEN2 antibody (Middle Region) (ABIN953114)

Target: KREMEN2 (Kringle Containing Transmembrane Protein 2 (KREMEN2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KREMEN2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-KREMEN2 Antibody

Binding Specificity: AA 247-276, Middle Region

Specificity: This antibody reacts to KREMEN2.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 247-276 amino acids from the Central region of human KREMEN2

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for KREMEN2

Target: KREMEN2 (Kringle Containing Transmembrane Protein 2 (KREMEN2))

Alternative Name: Kremen Protein 2

Background: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.Synonyms: Dickkopf receptor 2, KREMEN2, KRM2, Kringle domain-containing transmembrane protein 2, Kringle-containing protein marking the eye and the nose

Gene ID: 79412

NCBI Accession: NP_078783

Pathways: WNT Signaling