MLH1 antibody (Middle Region)

Catalog No. ABIN953460

The Rabbit Polyclonal anti-MLH1 antibody (ABIN953460) specifically detects MLH1 in WB, FACS and EIA. The antibody is reactive with Human samples.

Quick Overview for MLH1 antibody (Middle Region) (ABIN953460)

Target: MLH1 (MutL Homolog 1 (MLH1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLH1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Product Details anti-MLH1 Antibody

Binding Specificity: AA 459-488, Middle Region

Specificity: This antibody recognizes MLH1.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Purified through a Protein A column followed by peptide affinity purification

Immunogen: Synthetic peptide - KLH conjugated - corresponding to the central region (between 459-488aa) of human MLH1.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for MLH1

Target: MLH1 (MutL Homolog 1 (MLH1))

Alternative Name: MLH1

Background: The MLH1 gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.Synonyms: COCA2, DNA mismatch repair protein Mlh1

Gene ID: 4292

NCBI Accession: NP_000240

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response