BTBD14A antibody (C-Term)

Catalog No. ABIN953595

This anti-BTBD14A antibody is a Rabbit Polyclonal antibody detecting BTBD14A in WB and EIA. Suitable for Human.

Quick Overview for BTBD14A antibody (C-Term) (ABIN953595)

Target: BTBD14A (BTB (POZ) Domain Containing 14A (BTBD14A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BTBD14A antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-BTBD14A Antibody

Binding Specificity: AA 472-502, C-Term

Specificity: This antibody recognizes Human NACC2 / BTBD14A (C-term).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 472-502 amino acids from the C-terminal region of human NACC2 / BTBD14A

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for BTBD14A

Target: BTBD14A (BTB (POZ) Domain Containing 14A (BTBD14A))

Alternative Name: NACC2 / BTBD14A

Background: BTBD14A (BTB/POZ domain-containing protein 14A), also known as BTBD14, is a 587 amino acid protein that contains one BTB/POZ domain. The BTB/POZ domain mediates homomeric and heteromeric POZ-POZ interactions and is common to transcriptional regulators involved in chromatin modeling. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. This suggests that BTBD14A may play a role in transcription regulation.Synonyms: BTB/POZ domain-containing protein 14A, Nucleus accumbens-associated protein 2

Molecular Weight: 62837 Da

Gene ID: 138151

NCBI Accession: NP_653254

Pathways: Positive Regulation of Response to DNA Damage Stimulus