SPG7 antibody (Middle Region)

Catalog No. ABIN953990

Product Details anti-SPG7 Antibody

Target: SPG7 (Spastic Paraplegia 7 (SPG7))

Binding Specificity: AA 114-141, Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPG7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Paraplegin / SPG7.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Purified through a Protein A column followed by peptide affinity purification

Immunogen: Synthetic peptide - KLH conjugated - corresponding to the central region (between 114-141aa) of human Paraplegin / SPG7

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SPG7

Target: SPG7 (Spastic Paraplegia 7 (SPG7))

Alternative Name: Paraplegin / SPG7 (SPG7 Products)

Synonyms: CAR antibody, CMAR antibody, PGN antibody, SPG5C antibody, AI452278 antibody, AU015315 antibody, Cmar antibody, SPG7, paraplegin matrix AAA peptidase subunit antibody, SPG7 antibody, Spg7 antibody

Background: The SPG7 gene encodes a nuclear-encoded mitochondrial metalloprotease protein that is a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 7.Synonyms: CAR, CMAR, PGN, Spastic paraplegia 7 protein

Gene ID: 6687

NCBI Accession: NP_003110