PKM2 antibody (N-Term)
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- Target See all PKM2 Antibodies
- PKM2 (Pyruvate Kinase M2 (PKM2))
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Binding Specificity
- AA 123-153, N-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PKM2 antibody is un-conjugated
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificity
- This antibody recognizes Human PKM2 (N-term).
- Purification
- Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
- Immunogen
- KLH conjugated synthetic peptide between 123~153 amino acids from the N-terminal region of Human PKM2. Genename: PKM2
- Isotype
- Ig Fraction
- Top Product
- Discover our top product PKM2 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/mL
- Buffer
- PBS, 0.09 % Sodium Azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- PKM2 (Pyruvate Kinase M2 (PKM2))
- Alternative Name
- PKM2 (PKM2 Products)
- Background
- PKM2 encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis.Synonyms: CTHBP, Cytosolic thyroid hormone-binding protein, M2-PK, OIP-3, OIP3, Opa-interacting protein 3, PK2, PK3, PKM, Pyruvate kinase 2/3, Pyruvate kinase M1/M2, Pyruvate kinase isozymes M1/M2, Pyruvate kinase muscle, Pyruvate kinase muscle isozyme, THBP1
- Molecular Weight
- 57937 Da
- Gene ID
- 5315
- NCBI Accession
- NP_001193725
- Pathways
- Warburg Effect
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