Presenilin 1 antibody

Catalog No. ABIN962082

This anti-Presenilin 1 antibody is a Rabbit Polyclonal antibody detecting Presenilin 1 in WB and ELISA. Suitable for Human, Mouse, Rat and Xenopus laevis.

Quick Overview for Presenilin 1 antibody (ABIN962082)

Target: Presenilin 1 (PSEN1)

Reactivity: Human, Mouse, Rat, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Presenilin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Presenilin 1 Antibody

Specificity: The immunogenic peptide sequences from Presenilin-1, shows 100 % homology to human, xenopus, mouse and rat Presenilin-1. There is no significant homology with other known proteins. The Presenilin-1 antibody cross-reactivity in other species is not known. The appropriate control immunogenic peptides are also available to confirm specificity of antibodies.

Purification: Immunoaffinity purified

Immunogen: 15 mer peptide locating to the large hydrophilic loop of human or mouse Presenilin-1.

Isotype: IgG

Application Details

Application Notes: Approved: ELISA (1:10000 - 1:100000), WB (1:1000 - 1:5000)

Usage: Suitable for use in Immunofluorescence, ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry. Western Blot: 1:1000-1:5000 for neat serum and 1-10 μg/mL for affinity pure using ECL. ELISA: 1:10000-1:100000 using 50-100 ng of control peptide/well. Immunoprecipitations: We recommend 5-10 μL neat serum or 1-10 μg affinity pure antibody per 100 μg of tissue. Immunohistochemistry & Immunofluorescence: We recommend the use of affinity purified antibody at 2-20 μg/mL.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Sterile PBS. Resuspend to 100 μL

Concentration: Lot specific

Buffer: PBS, 0.1 % BSA.

Handling Advice: Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for Presenilin 1

Target: Presenilin 1 (PSEN1)

Alternative Name: PSEN1 / Presenilin 1

Background: Name/Gene ID: PSEN1
Subfamily: Aspartic A22A
Family: protease

Synonyms: PSEN1, AD3, Alzheimer disease 3, FAD, Protein S182, PS1, S182, PS-1, PSNL1, Presenilin 1, Presenilin-1

Gene ID: 5663

UniProt: P49768

Pathways: Notch Signaling, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport