ARL6 antibody (N-Term)

Catalog No. ABIN965594

Product Details anti-ARL6 Antibody

Target: ARL6 (ADP Ribosylation Factor Like GTPase 6 (ARL6))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARL6 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human ARL6 (ADP-ribosylation factorlike protein 6)

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-ARL6 antibody (ABIN965594)

Chiang, Nishimura, Searby, Elbedour, Carmi, Ferguson, Secrist, Braun, Casavant, Stone, Sheffield: "Comparative genomic analysis identifies an ADP-ribosylation factor-like gene as the cause of Bardet-Biedl syndrome (BBS3)." in: American journal of human genetics, Vol. 75, Issue 3, pp. 475-84, (2004) (PubMed).

Fan, Esmail, Ansley, Blacque, Boroevich, Ross, Moore, Badano, May-Simera, Compton, Green, Lewis, van Haelst, Parfrey, Baillie, Beales, Katsanis, Davidson, Leroux: "Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome." in: Nature genetics, Vol. 36, Issue 9, pp. 989-93, (2004) (PubMed).

Ingley, Williams, Walker, Tsai, Colley, Sayer, Tilbrook, Sarna, Beaumont, Klinken: "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit." in: FEBS letters, Vol. 459, Issue 1, pp. 69-74, (1999) (PubMed).

Jacobs, Schilf, Fliegert, Koling, Weber, Schürmann, Joost: "ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal." in: FEBS letters, Vol. 456, Issue 3, pp. 384-8, (1999) (PubMed).

Target Details for ARL6

Target: ARL6 (ADP Ribosylation Factor Like GTPase 6 (ARL6))

Alternative Name: ARL6 (ARL6 Products)

Synonyms: BBS3 antibody, RP55 antibody, 1110018H24Rik antibody, 2210411E14Rik antibody, zgc:101762 antibody, arl6 antibody, ADP ribosylation factor like GTPase 6 antibody, ADP-ribosylation factor-like 6 antibody, ADP-ribosylation factor like GTPase 6 antibody, ADP-ribosylation factor-like protein 6 antibody, ADP ribosylation factor like GTPase 6 L homeolog antibody, ARL6 antibody, Arl6 antibody, arl6 antibody, arl-6 antibody, arl6.L antibody

Background: ARL6 (ADP-ribosylation factor-like protein 6) belongs to the ARF family of GTP-binding proteins. ARF proteins are important regulators of cellular traffic and are the founding members of an expanding family of homologous proteins and genomic sequences. They depart from other small GTP-binding proteins by a unique structural device that implements front-back communication from the N-terminus to the nucleotide-binding site. Studies of the mouse ortholog of this protein suggest an involvement in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation.