Dynamin 1-Like antibody (C-Term)

Catalog No. ABIN966011

Product Details anti-Dynamin 1-Like Antibody

Target: Dynamin 1-Like (DNM1L)

Binding Specificity: C-Term

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dynamin 1-Like antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of mouse Drp1(Dynamin-related Protein 1)

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C

References for anti-Dynamin 1-Like antibody (ABIN966011)

Etxebarria, Terrones, Yamaguchi, Landajuela, Landeta, Antonsson, Wang, Basañez: "Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements." in: The Journal of biological chemistry, Vol. 284, Issue 7, pp. 4200-12, (2009) (PubMed).

Honda, Hirose: "Stage-specific enhanced expression of mitochondrial fusion and fission factors during spermatogenesis in rat testis." in: Biochemical and biophysical research communications, Vol. 311, Issue 2, pp. 424-32, (2003) (PubMed).

Yoon, Krueger, Oswald, McNiven: "The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1." in: Molecular and cellular biology, Vol. 23, Issue 15, pp. 5409-20, (2003) (PubMed).

Li, Gould: "The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11." in: The Journal of biological chemistry, Vol. 278, Issue 19, pp. 17012-20, (2003) (PubMed).

Chen, Hwang, Howng, Chou, Hong: "Three rat brain alternative splicing dynamin-like protein variants: interaction with the glycogen synthase kinase 3beta and action as a substrate." in: Biochemical and biophysical research communications, Vol. 268, Issue 3, pp. 893-8, (2000) (PubMed).

Target Details for Dynamin 1-Like

Target: Dynamin 1-Like (DNM1L)

Alternative Name: Drp1 (DNM1L Products)

Background: Drp1(Dynamin-related Protein 1) caused global morphological changes in mitochondrial outer membrane-like liposomes, but DLP1 or Drp1 did not stimulate BAXpermeabilizing function in the absence or presence of Bif-1. The human homolog is a GTPase that is necessary for peroxisome division [RGD]. Mitochondrial fragmentation in acute kidney injury involves the activation of mitochondrial fission via Drp1. Drp1 contains Ras_like_GTPase domain. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes