ELK1 antibody (ELK1, Member of ETS Oncogene Family)

Details for Product anti-ELK1 Antibody No. ABIN966064, Supplier: Log in to see
Antigen
  • Elk-1
  • Xelk
  • Xelk-1
  • elk-1
  • elk1
  • ELK1, ETS transcription factor
  • ELK1, member of ETS oncogene family
  • ETS domain-containing protein Elk-1
  • ELK1, member of ETS oncogene family S homeolog
  • ELK1
  • Elk1
  • Tsp_02690
  • elk1
  • elk1.S
Alternatives
anti-Human ELK1 antibody for Western Blotting
Reactivity
Human
342
211
198
22
18
14
13
12
7
6
5
3
3
2
1
1
Host
303
41
Clonality
Monoclonal
Conjugate
This ELK1 antibody is un-conjugated
6
6
6
4
4
3
3
3
3
3
3
3
3
3
3
2
2
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
230
157
115
58
48
40
38
9
7
6
3
2
1
1
Options
Supplier
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Isotype IgG1
Specificity Ni-NTA purified truncated recombinant ELK1 expressed in E. Coli strain BL21 (DE3).
Purification Ascites.
Plasmids, Primers & others Plasmids, Primers & others ELK1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name ELK1 (ELK1 Antibody Abstract)
Background The transcription factor ELK1 is a family of member of ETS oncogene family and of the ternary complex factor (TCF) subfamily,which is located on chromosome Xp11.2 and stimulates transcription. binds to purine-rich DNA sequences. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. Elk1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C terminus,It appears to be a direct target of activated MAP kinase. Biochemical studies indicate that Elk1 is a good substrate for MAP kinase, the kinetics of Elk1phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block Elk1 activation in vivo. More recent studies have shown that Elk1 is also a target of the Stress Activated Kinase SAPK/JNK. Phosphorylation of Elk1 has also been implicated in synaptic plasticity in the adult hippocampus.
Gene ID 2002
Pathways MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor
Application Notes Western Blot: 1: 500- 1: 1,000
IHC(P): 1: 500- 1: 1,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Storage -20 °C
Product cited in: Hsieh, Wu, Tsai, Huang, Hsieh, Liu: "PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells." in: Biochemical and biophysical research communications, Vol. 339, Issue 1, pp. 217-25, 2005 (PubMed).

Gille, Strahl, Shaw: "Activation of ternary complex factor Elk-1 by stress-activated protein kinases." in: Current biology : CB, Vol. 5, Issue 10, pp. 1191-200, 1996 (PubMed).

Gille, Kortenjann, Thomae, Moomaw, Slaughter, Cobb, Shaw: "ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation." in: The EMBO journal, Vol. 14, Issue 5, pp. 951-62, 1995 (PubMed).

Rao, Huebner, Isobe, ar-Rushdi, Croce, Reddy: "elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints." in: Science (New York, N.Y.), Vol. 244, Issue 4900, pp. 66-70, 1989 (PubMed).

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