SAPK, JNK antibody

Catalog No. ABIN966993

Cited in 3+ publications. The Rabbit Polyclonal anti-SAPK, JNK antibody (ABIN966993) specifically detects SAPK, JNK in IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SAPK, JNK antibody (ABIN966993)

Target: SAPK, JNK

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Product Details

Specificity: SAPK/JNK (Ab-185) antibody detects endogenous levels of total SAPK/JNK protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human SAPK/JNK around the phosphorylation site of tyrosine 185(T-P-YP-V-V).

Application Details

Application Notes: IHC: 1:50-1:100.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References

Matsuyoshi, Shimada, Nakamura, Ishida, Konishi: "FADD phosphorylation is critical for cell cycle regulation in breast cancer cells." in: British journal of cancer, Vol. 94, Issue 4, pp. 532-9, (2006) (PubMed).

Ouwens, de Ruiter, van der Zon, Carter, Schouten, van der Burgt, Kooistra, Bos, Maassen, van Dam: "Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38." in: The EMBO journal, Vol. 21, Issue 14, pp. 3782-93, (2002) (PubMed).

Guan, Buckman, Springer, Morrison: "Both p38alpha(MAPK) and JNK/SAPK pathways are important for induction of nitric-oxide synthase by interleukin-1beta in rat glomerular mesangial cells." in: The Journal of biological chemistry, Vol. 274, Issue 51, pp. 36200-6, (2000) (PubMed).

Target Details

Target: SAPK, JNK

Alternative Name: SAPK/JNK