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Ezrin antibody (pThr567)

EZR Reactivity: Human, Mouse, Rat WB, IHC (f) Host: Mouse Monoclonal J37-954-281-307 unconjugated
Catalog No. ABIN967590
  • Target See all Ezrin (EZR) Antibodies
    Ezrin (EZR)
    Binding Specificity
    • 29
    • 16
    • 12
    • 11
    • 9
    • 9
    • 9
    • 8
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr567
    Reactivity
    • 154
    • 81
    • 74
    • 8
    • 7
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 142
    • 11
    • 3
    • 2
    Mouse
    Clonality
    • 138
    • 19
    Monoclonal
    Conjugate
    • 90
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This Ezrin antibody is un-conjugated
    Application
    • 118
    • 54
    • 26
    • 17
    • 16
    • 13
    • 13
    • 13
    • 10
    • 9
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Brand
    BD Pharmingen™
    Cross-Reactivity (Details)
    Predicted: Mouse, Rat
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Phosphorylated Ezrin Peptide
    Clone
    J37-954-281-307
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product EZR Primary Antibody
  • Comment

    Related Products: ABIN967389, ABIN968533, ABIN968534, ABIN968057

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store undiluted at 4°C.
  • Gautreau, Louvard, Arpin: "Morphogenic effects of ezrin require a phosphorylation-induced transition from oligomers to monomers at the plasma membrane." in: The Journal of cell biology, Vol. 150, Issue 1, pp. 193-203, (2000) (PubMed).

    Tran Quang, Gautreau, Arpin, Treisman: "Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes." in: The EMBO journal, Vol. 19, Issue 17, pp. 4565-76, (2000) (PubMed).

    Gautreau, Poullet, Louvard, Arpin: "Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 13, pp. 7300-5, (1999) (PubMed).

  • Target
    Ezrin (EZR)
    Alternative Name
    Ezrin (EZR Products)
    Synonyms
    CVIL antibody, CVL antibody, VIL2 antibody, ezr antibody, vil2 antibody, wu:fc05c03 antibody, wu:fj31d06 antibody, cvil antibody, cvl antibody, Vil2 antibody, AW146364 antibody, R75297 antibody, p81 antibody, ezr.S antibody, ezrin antibody, ezrin b antibody, ezrin L homeolog antibody, EZR antibody, ezrb antibody, ezr antibody, Ezr antibody, ezr.L antibody
    Background
    Ezrin is a member of the ERM (Ezrin-Radixin-Moesin) family of proteins that can function as a crosslinker between the actin cytoskeleton and the plasma membrane of the cell. Phosphorylation of threonine residues (Thr567 on Ezrin, Thr564 on Radixin and Thr558 on Moesin) has been reported to occur with stimulation of growth factors and is important for cytoskeletal rearrangements. Phosphorylation of Thr567 at the C-terminal F actin-binding domain has been reported to activate the conversion of Ezrin from a dormant soluble form in the cytosol to a membrane- and actin-binding conformation.
    In addition to its reactivity to the human species, the peptide used to generate this antibody is either identical or has homology to analogous regions of mouse and rat Ezrin, Radixin and Moesin. The J37-954.281.307 monoclonal antibody has been reported to recognize phosphorylated T567 on active Ezrin in addition to crossreacting on phosphorylated T564 on Radixin and phosphorylated T558 on Moesin.
    Molecular Weight
    75-80 kDa
    Pathways
    Maintenance of Protein Location
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