CLOCK antibody

Catalog No. ABIN969059

The Mouse Monoclonal anti-CLOCK antibody has been validated for ELISA and ICC. It is suitable to detect CLOCK in samples from Human. There are 2+ publications available.

Quick Overview for CLOCK antibody (ABIN969059)

Target: CLOCK (Clock Homolog (Mouse) (CLOCK))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CLOCK antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC)

Clone: 8F7

Product Details anti-CLOCK Antibody

Purpose: CLOCK Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human CLOCK expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-CLOCK antibody (ABIN969059)

Kuo, Chen, Yeh, Hou, Chang, Hsu, Chang: "Disturbance of circadian gene expression in breast cancer." in: Virchows Archiv : an international journal of pathology, Vol. 454, Issue 4, pp. 467-74, (2009) (PubMed).

Lee, Paik, Kang, Lim, Kim: "Allelic variants interaction of CLOCK gene and G-protein beta3 subunit gene with diurnal preference." in: Chronobiology international, Vol. 24, Issue 4, pp. 589-97, (2007) (PubMed).

Target Details for CLOCK

Target: CLOCK (Clock Homolog (Mouse) (CLOCK))

Alternative Name: CLOCK

Background: This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1.

Molecular Weight: 95 kDa

Gene ID: 9575

UniProt: O15516

Pathways: Regulation of Lipid Metabolism by PPARalpha, Photoperiodism