Cortactin antibody

Catalog No. ABIN969073

This Mouse Monoclonal antibody specifically detects Cortactin in WB, IHC and ELISA. It exhibits reactivity toward Human and Mouse and has been mentioned in 2+ publications.

Quick Overview for Cortactin antibody (ABIN969073)

Target: Cortactin (CTTN)

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cortactin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 4C6

Product Details anti-Cortactin Antibody

Purpose: CTTN Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human CTTN expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Cortactin antibody (ABIN969073)

Li, Lin, Liu, Xie: "[Expression and clinical significance of EMS1 gene in gastric carcinoma]." in: Ai zheng = Aizheng = Chinese journal of cancer, Vol. 27, Issue 3, pp. 323-6, (2008) (PubMed).

Lin, Su, Tsai, Sheu, Jin: "Association of cortactin, fascin-1 and epidermal growth factor receptor (EGFR) expression in ovarian carcinomas: correlation with clinicopathological parameters." in: Disease markers, Vol. 25, Issue 1, pp. 17-26, (2008) (PubMed).

Target Details for Cortactin

Target: Cortactin (CTTN)

Alternative Name: CTTN

Background: This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. (provided by RefSeq)

Molecular Weight: 80 kDa

UniProt: Q14247

Pathways: MAPK Signaling