PERK antibody

Catalog No. ABIN969093

Product Details anti-PERK Antibody

Target: PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PERK antibody is un-conjugated

Application: ELISA

Purpose: EIF2AK3 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human EIF2AK3 expressed in E. Coli.

Clone: 5G5

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-PERK antibody (ABIN969093)

Yamaguchi, Larkin, Lara-Lemus, Ramos-Castañeda, Liu, Arvan: "Endoplasmic reticulum (ER) chaperone regulation and survival of cells compensating for deficiency in the ER stress response kinase, PERK." in: The Journal of biological chemistry, Vol. 283, Issue 25, pp. 17020-9, (2008) (PubMed).

Liang, Yang, Wang, Li, Tang, Chen: "Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2alpha." in: Human molecular genetics, Vol. 17, Issue 20, pp. 3254-62, (2008) (PubMed).

Target Details for PERK

Target: PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))

Alternative Name: EIF2AK3 (EIF2AK3 Products)

Background: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

Molecular Weight: 125 kDa

Gene ID: 9451

UniProt: Q9NZJ5

Pathways: Hormone Transport, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response