ERBB3 antibody (AA 1175-1275)

Catalog No. ABIN969112

This Mouse Monoclonal antibody specifically detects ERBB3 in IHC and ELISA. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for ERBB3 antibody (AA 1175-1275) (ABIN969112)

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ERBB3 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Clone: 3F10F6

Product Details anti-ERBB3 Antibody

Binding Specificity: AA 1175-1275

Purpose: ERBB3 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of ERBB3 (aa1175-1275) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-ERBB3 antibody (ABIN969112)

Sassen, Rochon, Wild, Hartmann, Hofstaedter, Schwarz, Brockhoff: "Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients." in: Breast cancer research : BCR, Vol. 10, Issue 1, pp. R2, (2008) (PubMed).

Sakai, Yokote, Murakami-Murofushi, Tamura, Saijo, Nishio: "Pertuzumab, a novel HER dimerization inhibitor, inhibits the growth of human lung cancer cells mediated by the HER3 signaling pathway." in: Cancer science, Vol. 98, Issue 9, pp. 1498-503, (2007) (PubMed).

Target Details for ERBB3

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Alternative Name: ERBB3

Background: ERBB3: v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian). This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

UniProt: P21860

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway