IKBKB antibody

Catalog No. ABIN969212

There are 4+ publications for this product available. The Mouse Monoclonal anti-IKBKB antibody is suitable to detect IKBKB in samples from Human. It has been validated for ELISA.

Quick Overview for IKBKB antibody (ABIN969212)

Target: IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IKBKB antibody is un-conjugated

Application: ELISA

Clone: 10A2

Product Details anti-IKBKB Antibody

Purpose: IKBKB Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of IKBKB expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-IKBKB antibody (ABIN969212)

Park, Song, Kim, Son, Lee, Yoon, Kim, Park, Song, Hwang, Jung, Hong: "Cobrotoxin inhibits NF-kappa B activation and target gene expression through reaction with NF-kappa B signal molecules." in: Biochemistry, Vol. 44, Issue 23, pp. 8326-36, (2005) (PubMed).

Kumar, Rajgopal, Pillai, Babu et al.: "Activation of nuclear transcription factor-kappa B is associated with the induction of inhibitory kappa B kinase-beta and involves differential activation of protein kinase C and protein tyrosine ..." in: Neuroscience letters, Vol. 340, Issue 2, pp. 139-42, (2003) (PubMed).

Peet, Li: "IkappaB kinases alpha and beta show a random sequential kinetic mechanism and are inhibited by staurosporine and quercetin." in: The Journal of biological chemistry, Vol. 274, Issue 46, pp. 32655-61, (2000) (PubMed).

Sarin, Lamba, Kumar, Misra, Murthy: "Comparison of endoscopic ligation and propranolol for the primary prevention of variceal bleeding." in: The New England journal of medicine, Vol. 340, Issue 13, pp. 988-93, (1999) (PubMed).

Target Details for IKBKB

Target: IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))

Alternative Name: IKBKB

Background: IKBKB(Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, also called IKK2/IKKB), is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.

Molecular Weight: 43 kDa

Gene ID: 3551

UniProt: O14920

Pathways: NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins