LCK antibody
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- Target See all LCK Antibodies
- LCK (Lymphocyte-Specific Protein tyrosine Kinase (LCK))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This LCK antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Purification
- purified
- Immunogen
- Purified recombinant fragment of human Lck expressed in E. coli.
- Clone
- 8E5F9
- Isotype
- IgG2a
- Top Product
- Discover our top product LCK Primary Antibody
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- Application Notes
- ELISA: 1:10000, WB: 1:500 - 1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- 4°C, -20°C for long term storage
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A constitutively active Lck kinase promotes cell proliferation and resistance to apoptosis through signal transducer and activator of transcription 5b activation." in: Molecular cancer research : MCR, Vol. 4, Issue 1, pp. 39-45, (2006) (PubMed).
: "A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejection." in: The Journal of pharmacology and experimental therapeutics, Vol. 315, Issue 1, pp. 36-41, (2005) (PubMed).
: "The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 5683-91, (2002) (PubMed).
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A constitutively active Lck kinase promotes cell proliferation and resistance to apoptosis through signal transducer and activator of transcription 5b activation." in: Molecular cancer research : MCR, Vol. 4, Issue 1, pp. 39-45, (2006) (PubMed).
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- Target
- LCK (Lymphocyte-Specific Protein tyrosine Kinase (LCK))
- Alternative Name
- Lck (LCK Products)
- Synonyms
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zgc:136695 antibody, LCK antibody, Hck-3 antibody, Lsk antibody, Lskt antibody, p56
antibody, p56Lck antibody, LSK antibody, YT16 antibody, p56lck antibody, pp58lck antibody, P56LCK antibody, tkl antibody, Lck1 antibody, Lcktkr antibody, LCK proto-oncogene, Src family tyrosine kinase antibody, lymphocyte protein tyrosine kinase antibody, lck antibody, LCK antibody, Lck antibody - Background
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Description: Lck (lymphocyte-specific protein tyrosine kinase), with 509-amino acid protein (about 56 kDa), belongs to the Src non-receptor tyrosine kinases family. By virtue of common structural motifs, the Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Lck is expressed predominantly in T cells and is localized to the inner surface of the plasma membrane. Lck is activated after T cell stimulation and is required for T-cell proliferation and IL-2 production. Aberrant expression or activation of Lck kinase has been reported in both lymphoid and nonlymphoid malignancies. In addition, inhibition of Lck has been a target to prevent lymphocyte activation and acute rejection.
Aliases: YT16, p56lck, pp58lck
- Molecular Weight
- 56 kDa
- Gene ID
- 3932
- HGNC
- 3932
- Pathways
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
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