MAP2K6 antibody

Catalog No. ABIN969269

There is 1 publication for this product available. The Mouse Monoclonal anti-MAP2K6 antibody is suitable to detect MAP2K6 in samples from Human and Mouse. It has been validated for WB, ELISA, ICC and FACS.

Quick Overview for MAP2K6 antibody (ABIN969269)

Target: MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This MAP2K6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 3H12C8

Product Details anti-MAP2K6 Antibody

Purpose: MAP2K6 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human MAP2K6 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-MAP2K6 antibody (ABIN969269)

Arning, Monté, Hansen, Wieczorek, Jagiello, Akkad, Andrich, Kraus, Saft, Epplen: "ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease." in: Journal of molecular medicine (Berlin, Germany), Vol. 86, Issue 4, pp. 485-90, (2008) (PubMed).

Target Details for MAP2K6

Target: MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))

Alternative Name: MAP2K6

Background: This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. Tissue specificity: Isoform 2 is only expressed in skeletal muscle. Isoform 1, on the other hand, is found in skeletal muscle, heart, and in lesser extent in liver or pancreas .

Molecular Weight: 38 kDa

UniProt: P52564

Pathways: MAPK Signaling, TLR Signaling, Activation of Innate immune Response, Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades