PARL antibody (AA 112-167)

Catalog No. ABIN969340

This Mouse Monoclonal antibody specifically detects PARL in ELISA. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for PARL antibody (AA 112-167) (ABIN969340)

Target: PARL (Presenilin Associated, Rhomboid-Like (PARL))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PARL antibody is un-conjugated

Application: ELISA

Clone: 8C4B2

Product Details anti-PARL Antibody

Binding Specificity: AA 112-167

Purpose: PARL Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of PARL (aa112-167) expressed in E. Coli.

Isotype: IgG2b

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-PARL antibody (ABIN969340)

McQuibban, Saurya, Freeman: "Mitochondrial membrane remodelling regulated by a conserved rhomboid protease." in: Nature, Vol. 423, Issue 6939, pp. 537-41, (2003) (PubMed).

Pellegrini, Passer, Canelles, Lefterov, Ganjei, Fowlkes, Koonin, DAdamio: "PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2." in: Journal of Alzheimer's disease : JAD, Vol. 3, Issue 2, pp. 181-190, (2002) (PubMed).

Target Details for PARL

Target: PARL (Presenilin Associated, Rhomboid-Like (PARL))

Alternative Name: PARL

Background: PARL: presenilin associated, rhomboid-like. This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene ID: 55486

UniProt: Q9H300

Pathways: Autophagy