PPARG antibody (AA 170-270)

Catalog No. ABIN969358

This Mouse Monoclonal antibody specifically detects PPARG in ELISA. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for PPARG antibody (AA 170-270) (ABIN969358)

Target: PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PPARG antibody is un-conjugated

Application: ELISA

Clone: 3A4A9

Product Details anti-PPARG Antibody

Binding Specificity: AA 170-270

Purpose: PPARG Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of PPARG (aa170-270) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-PPARG antibody (ABIN969358)

Canizales-Quinteros, Aguilar-Salinas, Ortiz-López, Rodríguez-Cruz, Villarreal-Molina, Coral-Vázquez, Huertas-Vázquez, Hernández-Caballero, López-Alarcón, Brito-Zurita, Domínguez-Banda et al.: "Association of PPARG2 Pro12Ala variant with larger body mass index in Mestizo and Amerindian populations of Mexico. ..." in: Human biology, Vol. 79, Issue 1, pp. 111-9, (2007) (PubMed).

Barna, Culver, Abraham, Malur, Bonfield, John, Farver, Drazba, Raychaudhuri, Kavuru, Thomassen: "Depressed peroxisome proliferator-activated receptor gamma (PPargamma) is indicative of severe pulmonary sarcoidosis: possible involvement of interferon gamma (IFN-gamma)." in: Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders, Vol. 23, Issue 2, pp. 93-100, (2007) (PubMed).

Target Details for PPARG

Target: PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))

Alternative Name: PPARG

Background: PPARG: peroxisome proliferator-activated receptor gamma. This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.

Gene ID: 5468

UniProt: P37231

Pathways: MAPK Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation