RPS6KA3 antibody

Catalog No. ABIN969386

There are 2+ publications for this product available. The Mouse Monoclonal anti-RPS6KA3 antibody is suitable to detect RPS6KA3 in samples from Human. It has been validated for WB, ELISA, FACS and ICC.

Quick Overview for RPS6KA3 antibody (ABIN969386)

Target: RPS6KA3 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RPS6KA3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 4E10

Product Details anti-RPS6KA3 Antibody

Purpose: RSK2 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human RSK2 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-RPS6KA3 antibody (ABIN969386)

Dehan, Bassermann, Guardavaccaro, Vasiliver-Shamis, Cohen, Lowes, Dustin, Huang, Taunton, Pagano: "betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis." in: Molecular cell, Vol. 33, Issue 1, pp. 109-16, (2009) (PubMed).

Cho, Yao, Pugliese, Malakhova, Bode, Dong: "A regulatory mechanism for RSK2 NH(2)-terminal kinase activity." in: Cancer research, Vol. 69, Issue 10, pp. 4398-406, (2009) (PubMed).

Target Details for RPS6KA3

Target: RPS6KA3 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3))

Alternative Name: RSK2

Background: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).

Molecular Weight: 80 kDa

Gene ID: 6197

UniProt: P51812

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades