SRC antibody (V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian))

Details for Product anti-SRC Antibody No. ABIN969418
Antigen
  • AW259666
  • pp60c-src
  • C-src1
  • CG7524
  • D-Src64B
  • D-src
  • DSRC64
  • DSrc
  • DSrc64
  • DSrc64B
  • Dm SRC1
  • DmHD-358
  • Dmel\CG7524
  • Dsrc
  • Dsrc64
  • Dsrc64B
  • HD-358
  • MRE5
  • SRC 64B
  • Src
  • Src1
  • Src64
  • c-src
  • dSrc
  • dsrc
  • src
  • src1
  • src64
  • src64B
  • src64b
  • ASV
  • SRC1
  • c-SRC
  • p60-Src
  • c-Src
  • PP60C-SCR
  • SDR
  • SRC proto-oncogene, non-receptor tyrosine kinase
  • uncharacterized LOC5574802
  • proto-oncogene tyrosine-protein kinase src
  • Rous sarcoma oncogene
  • Src oncogene at 64B
  • SRC
  • LOC5574802
  • CpipJ_CPIJ010659
  • Src
  • Src64B
Reactivity
Human
526
329
293
23
15
15
15
11
10
7
6
5
4
4
3
1
1
1
1
Host
Mouse
482
65
1
Clonality (Clone)
Monoclonal ()
Conjugate
This SRC antibody is un-conjugated
29
24
19
15
15
14
11
11
11
11
11
11
5
5
5
5
5
2
1
Application
Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
403
238
195
66
60
42
37
18
18
12
11
6
5
3
1
Options
Immunogen Purified recombinant fragment of human SRC expressed in E. Coli.
Clone 1F11
Isotype IgG1
Purification Ascites
Plasmids, Primers & others Plasmids, Primers & others SRC products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name SRC (SRC Antibody Abstract)
Background This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Molecular Weight 60 kDa
Gene ID 6714
HGNC 6714
Pathways JAK-STAT Signaling, Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process, Autophagy, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Image no. 1 for anti-V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) antibody (ABIN969418) Figure 5: Western blot analysis using SRC mouse mAb against MCF-7 (1), A431 (2), Hela...
Image no. 2 for anti-V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) antibody (ABIN969418) Figure 6: Western blot analysis using SRC mAb against human SRC (AA: 1-189) recombina...
Image no. 3 for anti-V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) antibody (ABIN969418) Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 n...
Image no. 4 for anti-V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) antibody (ABIN969418) Figure 2: Flow cytometric analysis of MCF-7 cells using SRC mouse mAb (green) and neg...
Image no. 5 for anti-V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) antibody (ABIN969418) Figure 3: Immunohistochemical analysis of paraffin-embedded bladder cancer tissues us...
Image no. 6 for anti-V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) antibody (ABIN969418) Figure 4: Immunohistochemical analysis of paraffin-embedded esophageal tissues using ...
Product cited in: Byers, Sen, Saigal, Diao, Wang, Nanjundan, Cascone, Mills, Heymach, Johnson: "Reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 22, pp. 6852-61, 2009 (PubMed).

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