TGFB1 antibody

Catalog No. ABIN969435

Cited in 2+ publications. The Mouse Monoclonal anti-TGFB1 antibody (Clone 4F9C10) (ABIN969435) specifically detects TGFB1 in ELISA. The antibody is reactive with Human samples.

Quick Overview for TGFB1 antibody (ABIN969435)

Target: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TGFB1 antibody is un-conjugated

Application: ELISA

Clone: 4F9C10

Product Details anti-TGFB1 Antibody

Purpose: TGF beta1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of TGF beta1 expressed in E. Coli.

Isotype: IgG2a

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-TGFB1 antibody (ABIN969435)

Saika: "TGFbeta pathobiology in the eye." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 86, Issue 2, pp. 106-15, (2006) (PubMed).

Boche, Cunningham, Docagne, Scott, Perry: "TGFbeta1 regulates the inflammatory response during chronic neurodegeneration." in: Neurobiology of disease, Vol. 22, Issue 3, pp. 638-50, (2006) (PubMed).

Target Details for TGFB1

Target: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Alternative Name: TGF beta1

Background: TGF beta(transforming growth factor beta), with 390-amino acid protein (about 43 kDa), is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. In mammals, three isoforms of TGFbeta, that is, beta1, beta2,and beta3,are known. TGF beta is one of numerous inhibitory factors produced by cancer cells that regulate antitumor immunity. TGF beta1 takes part in the local response in the course of primary lung cancer and TGFbeta1 is thought to be implicated in breast cancer progression.TGFbeta1 also plays a critical role in the downregulation of microglial responses minimizing brain inflammation and thus avoiding exacerbation of brain damage.

UniProt: P01137

Pathways: EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy, Cancer Immune Checkpoints