PDX1 antibody

Catalog No. ABIN969554

The Mouse Monoclonal anti-PDX1 antibody has been validated for ELISA and FACS. It is suitable to detect PDX1 in samples from Human. There are 2+ publications available.

Quick Overview for PDX1 antibody (ABIN969554)

Target: PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PDX1 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Clone: 2G12

Product Details anti-PDX1 Antibody

Purpose: PDX1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human PDX1 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-PDX1 antibody (ABIN969554)

Ota, Harada, Uehara, Hayama, Ishii: "Aberrant expression of TFF1, TFF2, and PDX1 and their diagnostic value in lobular endocervical glandular hyperplasia." in: American journal of clinical pathology, Vol. 135, Issue 2, pp. 253-61, (2011) (PubMed).

Mitnala, Pondugala, Guduru, Rabella, Thiyyari, Chivukula, Boddupalli, Hardikar, Reddy: "Reduced expression of PDX-1 is associated with decreased beta cell function in chronic pancreatitis." in: Pancreas, Vol. 39, Issue 6, pp. 856-62, (2010) (PubMed).

Target Details for PDX1

Target: PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))

Alternative Name: PDX1

Background: The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

Molecular Weight: 30.8 kDa

Gene ID: 3651

UniProt: P52945

Pathways: Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Hormone Transport, Carbohydrate Homeostasis, Chromatin Binding, Maintenance of Protein Location