ARID1A Products
(AT Rich Interactive Domain 1A (SWI-Like) (ARID1A))
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This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured ARID1A Categories
ARID1A Antibodies
High quality antibodies with extensive validation data.
Recommended ARID1A Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
Cat. No.
ABIN5649786
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (1)
Cat. No.
ABIN7144775
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
ELISA, WB, IF, ICC
Validations
- (1)
Cat. No.
ABIN6260038
Quantity
100 μL
Datasheet
Datasheet
Recommended ARID1A Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345571
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our ARID1A products
: "Identification of murine gammaherpesvirus 68 miRNA-mRNA hybrids reveals miRNA target conservation among gammaherpesviruses including host translation and protein modification machinery." in: PLoS pathogens, Vol. 15, Issue 8, pp. e1007843, (2019) (PubMed).: "ARID1A Expression is Down-Regulated by Oxidative Stress in Endometriosis and Endometriosis-Associated Ovarian Cancer." in: Translational oncogenomics, Vol. 9, pp. 1177272716689820, (2018) (PubMed).
: "smarce1 mutants have a defective endocardium and an increased expression of cardiac transcription factors in zebrafish." in: Scientific reports, Vol. 8, Issue 1, pp. 15369, (2018) (PubMed).
: "A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment." in: Oncotarget, Vol. 7, Issue 46, pp. 74931-74946, (2016) (PubMed).
: "Application of ARID1A to murine formalin-fixed paraffin embedded tissue using immunohistochemistry." in: F1000Research, Vol. 3, pp. 244, (2015) (PubMed).
: "Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers." in: Nature medicine, Vol. 21, Issue 3, pp. 231-8, (2015) (PubMed).
: "ARID1A expression in gastric adenocarcinoma: clinicopathological significance and correlation with DNA mismatch repair status." in: World journal of gastroenterology, Vol. 21, Issue 7, pp. 2159-68, (2015) (PubMed).
: "Decreased expression of ARID1A associates with poor prognosis and promotes metastases of hepatocellular carcinoma." in: Journal of experimental & clinical cancer research : CR, Vol. 34, pp. 47, (2015) (PubMed).
: "Integrated copy number and expression analysis identifies profiles of whole-arm chromosomal alterations and subgroups with favorable outcome in ovarian clear cell carcinomas." in: PLoS ONE, Vol. 10, Issue 6, pp. e0128066, (2015) (PubMed).
: "Altered expression of AT-rich interactive domain 1A in hepatocellular carcinoma." in: International journal of clinical and experimental pathology, Vol. 8, Issue 3, pp. 2763-70, (2015) (PubMed).
Synonyms and alternative names related to ARID1A
AT-rich interaction domain 1A (ARID1A), AT rich interactive domain 1A (SWI-like) (Arid1a), AT-rich interaction domain 1A (Arid1a), AT-rich interaction domain 1A (arid1a), AT rich interactive domain 1Aa (SWI-like) (arid1aa), 1110030E03Rik, ARID1A, B120, BAF250, BAF250a, BM029, C1orf4, ELD, hELD, hOSA1, MRD14, OSA1, Osa1, P270, SMARCF1, Smarcf1, wu:fb79b07, wu:fb95g08, zgc:171438Protein level used designations for ARID1A
- ARID domain-containing protein 1A
- AT-rich interactive domain-containing protein 1A
- BRG1-associated factor 250a
- OSA1 nuclear protein
- SWI-like protein
- SWI/SNF complex protein p270
- SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1
- brain protein 120
- chromatin remodeling factor p250
- osa homolog 1
- AT rich interactive domain 1A (Swi1 like)
- BAF250
- BRG1-associated factor 250
- SWI-SNF complex protein p270
- SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1
- Swi1 like
- AT rich interactive domain 1A (SWI-like)
- AT-rich interactive domain-containing protein 1A-like
- AT rich interactive domain 1Aa (SWI-like)
- fb79b07
- fb95g08
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