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ATP7A Products

(ATPase, Cu++ Transporting, alpha Polypeptide (ATP7A))
This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans-Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked cutis laxa, and occipital horn syndrome. [provided by RefSeq, Oct 2011].

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Featured ATP7A Categories

ATP7A Antibodies

High quality antibodies with extensive validation data.

ATP7A ELISA Kits

Reliable ELISA kits for a wide range of species.

ATP7A Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ATP7A Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, IF, ICC
Validations
  • (4)
Cat. No. ABIN2485193
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, IF, ICC
Validations
  • (4)
Cat. No. ABIN2485192
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, IF, ICC
Validations
  • (4)
Cat. No. ABIN2485189
Quantity 100 μg
Datasheet Datasheet

Recommended ATP7A ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6965087
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1127850
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1127849
Quantity 96 tests
Datasheet Datasheet

Recommended ATP7A Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1346155
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3089625
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3123304
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our ATP7A products

Wang, Zhu, Zhao, Wang: "miR-133a enhances the sensitivity of Hep-2 cells and vincristine-resistant Hep-2v cells to cisplatin by downregulating ATP7B expression." in: International journal of molecular medicine, Vol. 37, Issue 6, pp. 1636-42, (2016) (PubMed).

Ha, Doguer, Collins: "Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells." in: Metallomics : integrated biometal science, Vol. 8, Issue 9, pp. 963-972, (2016) (PubMed).

Montero-Melendez, Gobbetti, Cooray, Jonassen, Perretti: "Biased agonism as a novel strategy to harness the proresolving properties of melanocortin receptors without eliciting melanogenic effects." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 7, pp. 3381-8, (2015) (PubMed).

White, Kambe, Fulcher, Sachdev, Bush, Fritsche, Lee, Quinn, Petris: "Copper transport into the secretory pathway is regulated by oxygen in macrophages." in: Journal of cell science, Vol. 122, Issue Pt 9, pp. 1315-21, (2009) (PubMed).

White, Lee, Kambe, Fritsche, Petris: "A role for the ATP7A copper-transporting ATPase in macrophage bactericidal activity." in: The Journal of biological chemistry, Vol. 284, Issue 49, pp. 33949-56, (2009) (PubMed).

Setty, Tenza, Sviderskaya, Bennett, Raposo, Marks: "Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes." in: Nature, Vol. 454, Issue 7208, pp. 1142-6, (2008) (PubMed).

Schlief, West, Craig, Holtzman, Gitlin: "Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 40, pp. 14919-24, (2006) (PubMed).

Steveson, Ciccotosto, Ma, Mueller, Mains, Eipper: "Menkes protein contributes to the function of peptidylglycine alpha-amidating monooxygenase." in: Endocrinology, Vol. 144, Issue 1, pp. 188-200, (2002) (PubMed).

Synonyms and alternative names related to ATP7A

ATPase copper transporting alpha (ATP7A), ATPase, Cu++ transporting, alpha polypeptide (ATP7A), ATPase, Cu++ transporting, alpha polypeptide (atp7a), P-type ATPase (atp7a), ATP synthase subunit a (LOC100049514), ATPase, Cu++ transporting, alpha polypeptide (Atp7a), ATPase copper transporting alpha (atp7a), copper-transporting ATPase 1 (LOC412379), ATPase copper transporting alpha (Atp7a), ATP7A, Atp7a, atp7a, atpase, Blo, blotchy, br, brindled, cal, DDBDRAFT_0218568, DDBDRAFT_0235190, DDB_0218568, DDB_0235190, DSMAX, DXHXS1608e, I14, kal, MK, MNK, Mnk, Mo, mottled, SMAX3, wu:fc43e01, zgc:153422, zgc:158633

Protein level used designations for ATP7A

  • ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome)
  • ATPase, Cu++ transporting, alpha polypeptide
  • Menkes disease ATPase
  • calamity
  • copper-transporting ATPase 1
  • copper-transporting P-type ATPase
  • copper-transporting ATPase
  • ATPase protein
  • kaleidoscope
  • Copper-transporting ATPase 1
  • copper-transporting ATPase 1-like
  • Cu++-transporting P-type ATPase
  • Menkes disease-associated protein
  • copper pump 1
  • Menkes protein
  • menkes disease-associated protein homolog
  • copper transporting ATPase
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