CASP5 Products
(Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))
Categories
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc\\/Max\\/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein\\\\; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010].
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Featured CASP5 Categories
CASP5 Antibodies
High quality antibodies with extensive validation data.
CASP5 ELISA Kits
Reliable ELISA kits for a wide range of species.
CASP5 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CASP5 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, ICC, IP
Validations
- (4)
Cat. No.
ABIN7432568
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (4)
Cat. No.
ABIN654898
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS
Validations
- (5)
Cat. No.
ABIN3030309
Quantity
0.4 mL
Datasheet
Datasheet
Recommended CASP5 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965469
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954421
Quantity
96 tests
Datasheet
Datasheet
Recommended CASP5 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348109
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3090739
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3090740
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our CASP5 products
: "Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy. ..." in: The Journal of allergy and clinical immunology, (2019) (PubMed).: "Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye." in: The ocular surface, Vol. 14, Issue 2, pp. 242-54, (2016) (PubMed).
: "Desiccating Stress-Induced MMP Production and Activity Worsens Wound Healing in Alkali-Burned Corneas." in: Investigative ophthalmology & visual science, Vol. 56, Issue 8, pp. 4908-18, (2015) (PubMed).
: "Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens." in: Cell host & microbe, Vol. 16, Issue 2, pp. 249-56, (2014) (PubMed).
: "Expression and functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells." in: Investigative ophthalmology & visual science, Vol. 52, Issue 12, pp. 8646-56, (2011) (PubMed).
: "Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977." in: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34337-47, (2010) (PubMed).
: "Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis." in: Molecular and cellular biology, Vol. 29, Issue 13, pp. 3657-64, (2009) (PubMed).
: "A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) ..." in: Blood, Vol. 110, Issue 5, pp. 1664-74, (2007) (PubMed).
: "Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases." in: Cell, Vol. 117, Issue 5, pp. 561-74, (2004) (PubMed).
: "Interleukin-18." in: Journal of leukocyte biology, Vol. 73, Issue 2, pp. 213-24, (2003) (PubMed).
Synonyms and alternative names related to CASP5
caspase 5 (CASP5), caspase-5 (LOC100437308), CASP5, ICE(rel)III, ICEREL-III, ICH-3Protein level used designations for CASP5
- CASP-5
- ICE(rel)-III
- TY protease
- caspase 5, apoptosis-related cysteine protease
- caspase-5
- protease ICH-3
- protease TY
- caspase 5
- caspase 5, apoptosis-related cysteine peptidase
- caspase-5-like
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