C-Raf Proto-Oncogene Serine/Threonine Protein Kinase Proteins
(C-Raf Proto-Oncogene Serine/Threonine Protein Kinase (CRAF))
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008].
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Recommended C-Raf Proto-Oncogene Serine/Threonine Protein Kinase Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7396073
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3009008
Quantity
100 μg
Datasheet
Datasheet
Synonyms and alternative names related to C-Raf Proto-Oncogene Serine/Threonine Protein Kinase
Raf-1 proto-oncogene, serine/threonine kinase (RAF1), c-Raf, CRAF, NS5, Raf-1Protein level used designations for C-Raf Proto-Oncogene Serine/Threonine Protein Kinase
- Oncogene RAF1
- RAF proto-oncogene serine/threonine-protein kinase
- proto-oncogene c-RAF
- raf proto-oncogene serine/threonine protein kinase
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