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c-Rel Products

(REL proto-oncogene (c-Rel))
The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 [PubMed 18037997]).[supplied by OMIM, May 2008].

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Featured c-Rel Categories

c-Rel Antibodies

High quality antibodies with extensive validation data.

c-Rel ELISA Kits

Reliable ELISA kits for a wide range of species.

c-Rel Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended c-Rel Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (18)
Cat. No. ABIN6255382
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (5)
Cat. No. ABIN7189505
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC, ICC
Validations
  • (2)
  • (4)
Cat. No. ABIN968997
Quantity 100 μL
Datasheet Datasheet

Recommended c-Rel ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968923
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380693
Quantity 2 x 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6235949
Quantity 96 tests
Datasheet Datasheet

Recommended c-Rel Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124822
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3094924
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3133040
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our c-Rel products

Lee, Lee, Kim, Kim, Yang, Jeong, Seong: "Radiation Inhibits Interleukin-12 Production via Inhibition of C-Rel through the Interleukin-6/ Signal Transducer and Activator of Transcription 3 Signaling Pathway in Dendritic Cells." in: PLoS ONE, Vol. 11, Issue 1, pp. e0146463, (2016) (PubMed).

Calandria, Asatryan, Balaszczuk, Knott, Jun, Mukherjee, Belayev, Bazan: "NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival." in: Cell death and differentiation, Vol. 22, Issue 8, pp. 1363-77, (2015) (PubMed).

Boopathi, Hypolite, Zderic, Gomes, Malkowicz, Liou, Wein, Chacko: "GATA-6 and NF-κB activate CPI-17 gene transcription and regulate Ca2+ sensitization of smooth muscle contraction." in: Molecular and cellular biology, Vol. 33, Issue 5, pp. 1085-102, (2013) (PubMed).

Trynka, Zhernakova, Romanos, Franke, Hunt, Turner, Bruinenberg, Heap, Platteel, Ryan, de Kovel, Holmes, Howdle, Walters, Sanders, Mulder, Mearin, Verbeek, Trimble, Stevens, Kelleher, Barisani et al.: "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. ..." in: Gut, Vol. 58, Issue 8, pp. 1078-83, (2009) (PubMed).

Garbati, Gilmore: "Ser484 and Ser494 in REL are the major sites of IKK phosphorylation in vitro: evidence that IKK does not directly enhance GAL4-REL transactivation." in: Gene expression, Vol. 14, Issue 4, pp. 195-205, (2008) (PubMed).

Liu, Chen, Wang, Chang, Huang, Chung, Chen, Hung: "Role of transcriptional factors Sp1, c-Rel, and c-Jun in LPS-induced C/EBPdelta gene expression of mouse macrophages." in: Cellular and molecular life sciences : CMLS, Vol. 64, Issue 24, pp. 3282-94, (2008) (PubMed).

Copley, Totrov, Linnell, Field, Ragoussis, Udalova: "Functional conservation of Rel binding sites in drosophilid genomes." in: Genome research, Vol. 17, Issue 9, pp. 1327-35, (2007) (PubMed).

Banerjee, Liou, Sen: "c-Rel-dependent priming of naive T cells by inflammatory cytokines." in: Immunity, Vol. 23, Issue 4, pp. 445-58, (2005) (PubMed).

Houldsworth, Olshen, Cattoretti, Donnelly, Teruya-Feldstein, Qin, Palanisamy, Shen, Dyomina, Petlakh, Pan, Zelenetz, Dalla-Favera, Chaganti: "Relationship between REL amplification, REL function, and clinical and biologic features in diffuse large B-cell lymphomas." in: Blood, Vol. 103, Issue 5, pp. 1862-8, (2004) (PubMed).

Xiao, Shen, Hedvat, Moskowitz, Sussman, Filippa, Zelenetz, Houldsworth, Chaganti, Teruya-Feldstein: "Differential expression patterns of c-REL protein in classic and nodular lymphocyte predominant Hodgkin lymphoma." in: Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry, Vol. 12, Issue 3, pp. 211-5, (2004) (PubMed).

Synonyms and alternative names related to c-Rel

REL proto-oncogene, NF-kB subunit (REL), reticuloendotheliosis oncogene (Rel), RELA proto-oncogene, NF-kB subunit (Rela), REL proto-oncogene, NF-kB subunit (Rel), v-rel avian reticuloendotheliosis viral oncogene homolog (rel), v-rel avian reticuloendotheliosis viral oncogene homolog L homeolog (rel.L), ribonuclease A family member 2 pseudogene (ECRP), C-Rel, c-Rel, c-rel, NFkB, rel, rel-A, rel2, rel3, v-rel, xrel, Xrel2, Xrel3, zgc:100833

Protein level used designations for c-Rel

  • C-Rel proto-oncogene protein
  • oncogene REL, avian reticuloendotheliosis
  • proto-oncogene c-Rel
  • v-rel reticuloendotheliosis viral oncogene homolog
  • C-Rel protein
  • p68
  • nuclear factor kappa B subunit p65
  • transcription factor p65
  • v-rel reticuloendotheliosis viral oncogene homolog A
  • LOW QUALITY PROTEIN: proto-oncogene c-Rel
  • v-rel avian reticuloendotheliosis viral oncogene homolog L homeolog
  • v-rel avian reticuloendotheliosis viral oncogene homolog
  • eosinophil cationic-related protein
  • ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) pseudogene
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