C4BP Products
(C4b-Binding Protein)
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This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008].
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Latest Publications for our C4BP products
: "Biofilm formation avoids complement immunity and phagocytosis of Streptococcus pneumoniae." in: Infection and immunity, Vol. 81, Issue 7, pp. 2606-15, (2013) (PubMed).: "Functions of human complement inhibitor C4b-binding protein in relation to its structure." in: Archivum immunologiae et therapiae experimentalis, Vol. 52, Issue 2, pp. 83-95, (2004) (PubMed).
Synonyms and alternative names related to C4BP
complement component 4 binding protein (C4bp), complement component 4 binding protein beta (C4BPB), AI195242, C4BP, C4bpaProtein level used designations for C4BP
- C4b-binding protein
- C4b-binding protein beta chain
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