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CDKN2B Products

(Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

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This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].

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Featured CDKN2B Categories

CDKN2B Antibodies

High quality antibodies with extensive validation data.

CDKN2B Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CDKN2B Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF, IHC (p)
Validations
  • (6)
Cat. No. ABIN1497447
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF, FACS
Validations
  • (7)
Cat. No. ABIN3030647
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (4)
Cat. No. ABIN7182212
Quantity 100 μL
Datasheet Datasheet

Recommended CDKN2B Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1349020
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7419952
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3090897
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our CDKN2B products

Chen, Zhang, Mao, Zhou, Yu, Yin, Wu, Mou, Zhu: "ANRIL inhibits p15(INK4b) through the TGFβ1 signaling pathway in human esophageal squamous cell carcinoma." in: Cellular immunology, Vol. 289, Issue 1-2, pp. 91-6, (2014) (PubMed).

Ratovitski: "Phospho-?Np63?-dependent microRNAs modulate chemoresistance of squamous cell carcinoma cells to cisplatin: at the crossroads of cell life and death." in: FEBS letters, Vol. 587, Issue 16, pp. 2536-41, (2013) (PubMed).

Siddiqi, Terry, Matushansky: "Hiwi mediated tumorigenesis is associated with DNA hypermethylation." in: PLoS ONE, Vol. 7, Issue 3, pp. e33711, (2012) (PubMed).

Geyer: "Strategies to re-express epigenetically silenced p15(INK4b) and p21(WAF1) genes in acute myeloid leukemia." in: Epigenetics, Vol. 5, Issue 8, pp. 696-703, (2010) (PubMed).

Yoon, Kim, Yoon, Cho, Lim, Lee: "Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines: association of transforming growth factor beta1 (TGF-beta1)-mediated p27Kip1 expression." in: The Biochemical journal, Vol. 366, Issue Pt 2, pp. 613-21, (2002) (PubMed).

Synonyms and alternative names related to CDKN2B

cyclin dependent kinase inhibitor 2B (CDKN2B), Cyclin-dependent kinase 4 inhibitor B (cdn2b), cyclin-dependent kinase inhibitor 2B (cdkn2b), cyclin-dependent kinase inhibitor 2B L homeolog (cdkn2b.L), cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (Cdkn2b), cyclin-dependent kinase inhibitor 2B (Cdkn2b), AV083695, CDK4I, cdk4l, CDKN2A, ink4b, INK4B, INK4b, mts2, MTS2, p14-INK4b, p15, P15, p15(INK4b), p15ink4b, p15INK4b, tp15, TP15

Protein level used designations for CDKN2B

  • Cyclin-dependent kinase 4 inhibitor B
  • CDK inhibitory protein
  • CDK4B inhibitor
  • MTS-2
  • cyclin-dependent kinase 4 inhibitor B
  • cyclin-dependent kinases 4 and 6 binding protein
  • multiple tumor suppressor 2
  • p14-INK4b
  • p14_CDK inhibitor
  • p14_INK4B
  • p15 CDK inhibitor
  • p15-INK4b
  • p15_INK4B
  • cyclin-dependent kinase inhibitor p15
  • cyclin-dependent kinase inhibitor p15INK4b
  • cyclin-dependent kinase inhibitor protein
  • Cyclin dependent kinase inhibitor 2B (p15, inhibits CDK4)
  • cyclin dependant kinase inhibitor
  • cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
  • cyclin-dependent kinase inhibitor 2B
  • cyclin-dependent kinase inhibitor 2B (melanoma, p16, inhibits CDK4)
  • p15INK4b tumor suppressor
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